Design Proteins with RFD4-Proteina Using Reward-Guided Inference-Time Search
<img width="768" height="432" src="https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-768x432.png" class="webfeedsFeaturedVisual wp-post-image" alt="" style="display: block; margin-bottom: 5px; clear:both;max-width: 100%;" link_thumbnail="" decoding="async" srcset="https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-768x432.png 768w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-179x101.png 179w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-300x169.png 300w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-625x352.png 625w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-1536x864.png 1536w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-645x363.png 645w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-660x370.png 660w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-500x281.png 500w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-160x90.png 160w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-362x204.png 362w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-195x110.png 195w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-1024x576.png 1024w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-960x540.png 960w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2.webp 1672w" sizes="(max-width: 768px) 100vw, 768px" title="image4" />Protein design is a search problem. Choose amino acids for an eight-residue protein sequence and more than 25 billion combinations are possible. Choose amino...<img width="768" height="432" src="https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-768x432.png" class="webfeedsFeaturedVisual wp-post-image" alt="" style="display: block; margin-bottom: 5px; clear:both;max-width: 100%;" link_thumbnail="" decoding="async" loading="lazy" srcset="https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-768x432.png 768w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-179x101.png 179w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-300x169.png 300w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-625x352.png 625w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-1536x864.png 1536w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-645x363.png 645w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-660x370.png 660w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-500x281.png 500w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-160x90.png 160w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-362x204.png 362w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-195x110.png 195w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-1024x576.png 1024w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2-960x540.png 960w, https://developer-blogs.nvidia.com/wp-content/uploads/2026/10/image4-2.webp 1672w" sizes="auto, (max-width: 768px) 100vw, 768px" title="image4" /><p>Protein design is a search problem. Choose amino acids for an eight-residue protein sequence and more than 25 billion combinations are possible. Choose amino acids for a 100-residue protein sequence and the number of possibilities exceeds the number of atoms in the observable universe. Somewhere in that space is a protein that opens a path to a new therapy. There are too many combinations to…</p>
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